Cognitive Impairment and Psychiatric Morbidity in HIV+ Zambians with New-Onset Seizure


Kalungwana L, Elafros MA, Siddiqi OK, Bositis CM, Sikazwe I, Koralnik IJ, Theodore WH, Birbeck GL


Am J Trop Med Hyg. 2014 Oct 13. pii: 13-0758. [Epub ahead of print]


A prospective cohort study of new-onset seizure in people with human immunodeficiency virus (HIV) in Zambia is ongoing to determine the incidence of subsequent epilepsy and risk factors for epileptogenesis in this population. At enrollment, we evaluated this cohort for cognitive impairment and psychiatric morbidity. Over 50% of participants had cognitive impairment and significant psychiatric morbidity. Most participants had advanced HIV disease based on CD4+ T-cell count and World Health Organization stage, but we found no association between cognitive impairment or psychiatric morbidity and HIV disease staging.

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