Contribution of maternal immunity to decreased rotavirus vaccine performance in low and middle income countries


Mwila K, Chilengi R, Simuyandi M, Permar SR, Becker-Dreps S.


Clin Vaccine Immunol. 2016 Nov 9. pii: CVI.00405-16. [Epub ahead of print]


The role of maternal immunity received by infants either transplacentally or orally from breast milk on rotavirus vaccine (RV) performance is evaluated. Breast feeding withholding has no effect on vaccine response, but higher levels of transplacental rotavirus-specific IgG antibody contribute to reduced vaccine seroconversion. The gaps in knowledge on the factors associated with low RV efficacy in low and middle income countries (LMIC) remain and further research is needed to shed more light on these issues

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