Minimizing verification bias in cervical cancer screening of HIV-infected women


Allen C. Bateman, Carla J. Chibwesha, Groesbeck P. Parham


Int J Gynaecol Obstet. 2014 Oct 24. pii: S0020-7292(14)00540-2. doi: 10.1016/j.ijgo.2014.09.007. [Epub ahead of print]

HIV infection is associated with a higher incidence rate of cervical lesions and increased risk of cervical cancer [1]. New cervical cancer screening tests are available or in development, and many biomarkers hold promise for screening. It is important to evaluate the clinical performance characteristics of new screening tests in HIV-infected women, to inform possible introduction in this population. Histopathology is commonly used as the gold standard diagnosis in cervical cancer screening studies; however, verification bias can occur if none or only a subset of screen negatives receives histopathology.

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