Research

/Research
Research 2018-06-26T12:01:19+00:00

Research

Our research has ranged from small pharmacokinetic and behavioural studies to individual
and cluster-randomized trials to large multi-country programme evaluations.

We are committed to answering research questions relevant to improving health in Zambia. Our research aims to identify locally-relevant, culturally-acceptable, resource-appropriate, evidence-based interventions that will influence policy and thus raise healthcare service delivery in the public health sector.

We use the latest methodologies to generate evidence and advance knowledge.
Our clinical trials contribute to the development of new interventions; our implementation science provides solutions to system challenges; our qualitative research broadens understanding,
and our laboratory and immunology science improves impact. 

Our research teams are supported by a research and regulatory infrastructure with dedicated staff skilled in regulatory affairs, human subjects protections, Good Clinical Practices, quality control and assurance, data management, analysis, research pharmacy and laboratory. Our diverse Comunity Advisory Board guides our scientists on community engagement as we follow UNAIDS Good Participatory Practices. We disseminate our findings at local, regional and international meetings after sharing with the Ministry of Health. 

Implementation Science Unit

Accelerating Impactful Implementation Science Research, Dissemination, and Grant Development

Interest in programmatically relevant research has surged over the past decade as global health funders, policy makers, and implementers seek to maximize the effectiveness of interventions and translate scientific discoveries into service delivery innovation in “real world” clinical and public health settings. Implementation science flourishes at the interface of high-quality research and service delivery, two areas where CIDRZ is a leader in Zambia and sub-Saharan Africa. In 2017, the CIDRZ Implementation Science Unit was launched under the direction of Dr Michael Herce MD, MPH, MSc (Clinical Research and Epidemiology).

The unit supports the conceptualisation of implementation science studies and grants proposals within technical departments, leveraging existing CIDRZ project and programme data to spark implementation science research activities. Capacity is built in our investigators and technical staff to identify high-impact implementation science evidence gaps and research questions relevant to our programme areas and to develop methodologically sound research proposals and protocols, and conduct high-quality implementation science research.

Research Partnerships

We are an active member in these multi-site research partnerships.

CHASE – Cohort of HIV-Associated Seizures and Epilepsy in Zambia
EHPSA – Evidence for HIV Prevention in Southern Africa
PRET – Pragmatic Research Evaluation Trials
EDCTP – European & Developing Countries Clinical Trials Partnership
IeDEA – International Epidemiological Databases to Evaluate AIDS in Southern Africa
CQUIN – HIV Coverage, Quality and Impact Network

Clinical Trial Networks

Since 2002 CIDRZ has conducted clinical trials funded by the United States National Institutes of Health, Division of AIDS. Currently, we are conducting HIV Vaccine Trials Network (HVTN) and the International Maternal Pediatric Adolescent AIDS Clinical Trials group (IMPAACT) research. We are also conducting TB vaccine research for the AERAS TB Vaccines Network.

Publications

Research knowledge is meant to be shared and our research and programme implementation manuscripts undergo peer-review prior to publication. Our research output contributes to the development of open-source scientific publications, National Guidelines and Training Manuals, to programme Implementation Toolkits. Read our most recent publications.